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COVID lethality per virus dropped by 10x in MA, pre-vaccine. Compared to that, hypothetical vaccine benefit is just noise. https://github.com/s1rh3nry/covid_calc#readme

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You can't infer case rates from RNA flow, because RNA flows is dependent on immune status and SARS-CoV-2 variant.

This won't really shed much light either, but still can't hurt to look at other countries' data:

https://substack.pervaers.com/misc/Dutch_sewage_per_case.png

https://substack.pervaers.com/misc/Dutch_cases.png

https://substack.pervaers.com/misc/Dutch_sewage.png

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Do you think this would look different if you looked only at the older population that was most affected by COVID?

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Not really:

https://substack.pervaers.com/USA_Misc/regr_over_time_65%2B_0-64_mortality_compared_to_4yr_earlier.png

These are just deaths per 100k compared to 4 years earlier. Pretty much the same picture when comparing to 3 years earlier.

1 regression per week.

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Thank you.

Even if you don't like COVID deaths as a variable, I recommend looking into non-COVID deaths.

These auto-regressions are also very informative:

https://years.pervaers.com/

Displayed is average weekly excess mortality for the 85+ group, but I'm not 100% sure, might be 65+.

What's remarkable is that excess mortality in 2021 predicts excess mortality in 2022 (Pearson 0.88 across states).

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